How bacterial metabolites can disrupt mucosal immunity

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Location
Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
A/Prof Glen Scholz glenms@unimelb.edu.au 9341 1545 Personal web page

Summary You will investigate how bacterial metabolic products affect the inflammatory and antibacterial functions of mucosal epithelial cells. The new knowledge you create will help us to understand how changes in the bacterial composition of biofilms can disrupt host-bacteria homeostasis and thereby cause disease.

Project Details

The mucosal surfaces of the body are colonised by large numbers of bacteria. Some of the metabolites produced by the bacteria (e.g. short-chain fatty acids) can affect the functions of immune cells. We recently demonstrated that these metabolites can also affect the host defence functions of oral mucosal epithelial cells. Oral epithelial cells play critical roles in preventing infection because they are the first cells to encounter pathogens and subsequently activate the host immune response. In this project you will investigate how bacterial metabolites can affect specific host defence functions of oral mucosal epithelial cells. The project will provide opportunities to develop skills in mammalian and bacterial cell culture, manipulating gene expression, analysis of cell signalling and gene expression, immunofluorescence confocal microscopy, critical thinking, scientific writing, and oral communication.



Faculty Research Themes

Infection and Immunology

School Research Themes

Oral Infection and Immunity



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Research Node

Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute

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