How bacterial metabolites can disrupt mucosal host defence

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Melbourne Dental School
Location
Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
A/Prof Glen Scholz glenms@unimelb.edu.au 9341 1545 Personal web page

Summary You will investigate how bacterial metabolic products affect the inflammatory functions of mucosal epithelial cells. The new knowledge you create will help us understand how changes in biofilm composition can disrupt host-bacteria homeostasis and cause disease.

Project Details

Bacterial metabolic products (e.g. short-chain fatty acids) have been shown to affect the functions of immune cells, in part through effects on host epigenetic mechanisms. We have recently established that the host defence functions of oral mucosal epithelial cells are also regulated by epigenetic mechanisms, and affected by bacterial metabolites. In this project you will investigate how changes in the types of bacteria that colonise the oral cavity could cause inflammatory diseases by disrupting epigenetic mechanisms that promote host-bacteria homeostasis. The new knowledge you create will help us develop better ways to prevent bacterial-mediated diseases.

This project will provide students with opportunities to develop skills in mouse models of bacterial infection, histological analysis, flow cytometry, mammalian and bacterial cell culture, gene silencing, cytokine analysis, immunofluorescence confocal microscopy, critical thinking and time management, scientific writing and oral communication.



Faculty Research Themes

Infection and Immunology

School Research Themes

Oral Infection and Immunity



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Melbourne Dental School

Research Node

Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute

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