Characterisation of potential virulence factors secreted by the type 9 secretion system of Porphyromonas gingivalis

Research Opportunity
Masters by Research, Honours
Number of Honour Places Available
2
Number of Master Places Available
2
Department
Melbourne Dental School
Location
Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
Dr Michelle Glew mglew@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
A/Prof Paul Veith

Summary Chronic periodontitis is an inflammatory disease causing the destruction of the supporting gum and bone of teeth.

Project Details

Porphyromonas gingivalis (Pg) is the major agent of this disease and is also associated with other diseases/conditions such as cardiovascular diseases, adverse pregnancy outcomes (preterm birth, low birth weight and pre-eclampsia), rheumatoid arthritis, diabetes, non-alcoholic fatty liver disease and Alzheimer’s disease. This emphasizes the importance of Pg host dissemination, immune evasion, immune modulatory tactics and Pg-induced inflammation. Pg possesses a type 9 secretion system (T9SS) which secretes abundant gingipain proteases that are involved in this disease process. Many other proteins are secreted by this T9SS but their functions are unknown. Recent structural analyses have predicted virulence functions for several of these T9SS substrates. The honours projects on offer will characterize these candidate virulence factors to further our understanding of the arsenal of virulence factors that P. gingivalis deploys and to identify potential vaccine candidates.



Faculty Research Themes

Infection and Immunology

School Research Themes

Oral Infection and Immunity, Population and Oral Health



Research Opportunities

Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Melbourne Dental School

Research Node

Bio21 Molecular Science and Biotechnology Institute

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