Bacterial chemotaxis and chronic disease
- Research Opportunity
- Honours students
- Number of Honour Places Available
- 1
- Number of Master Places Available
- 1
- Department / Centre
- Melbourne Dental School
- Location
- Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Prof Stuart Dashper | stuartgd@unimelb.edu.au |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Nada Slakeski | |||
| Dr Catherine Butler | |||
| Dr Samantha Byrne |
Summary In this project you will determine how T. denticola moves in response to stimuli using a custom-built flow cell and confocal scanning laser microscopy.
Project Details
Treponema denticola is a chemotactic, motile spirochaete that is an aetiological agent of chronic periodontitis. Its unique form of motility and chemotaxis enable it to move through highly viscous environments. It has twenty chemoreceptor proteins that enable it to respond to a range of stimulatory substances. In this project you will determine how T. denticola moves in response to stimuli using a custom-built flow cell and confocal scanning laser microscopy. You will have the opportunity to clone and express the T. denticola chemotaxis proteins and determine their substrate specificity using highly novel microarray technologies. The project will provide you with opportunities to develop skills in confocal microscopy, molecular biology, anaerobic bacterial culture, and protein expression.
Faculty Research Themes
School Research Themes
Research Opportunities
Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Node
Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology InstituteMDHS Research library
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