Bacterial chemotaxis and chronic disease

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Melbourne Dental School
Location
Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
Prof Stuart Dashper stuartgd@unimelb.edu.au
Co-supervisor Email Number Webpage
Dr Nada Slakeski
Dr Catherine Butler
Dr Samantha Byrne

Summary In this project you will determine how T. denticola moves in response to stimuli using a custom-built flow cell and confocal scanning laser microscopy.

Project Details

Treponema denticola is a chemotactic, motile spirochaete that is an aetiological agent of chronic periodontitis. Its unique form of motility and chemotaxis enable it to move through highly viscous environments. It has twenty chemoreceptor proteins that enable it to respond to a range of stimulatory substances. In this project you will determine how T. denticola moves in response to stimuli using a custom-built flow cell and confocal scanning laser microscopy. You will have the opportunity to clone and express the T. denticola chemotaxis proteins and determine their substrate specificity using highly novel microarray technologies. The project will provide you with opportunities to develop skills in confocal microscopy, molecular biology, anaerobic bacterial culture, and protein expression.


Faculty Research Themes

Infection and Immunology

School Research Themes

Oral Infection and Immunity



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Melbourne Dental School

Research Node

Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute

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