Antiviral functions of the novel inflammatory cytokine IL-36G

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Location
Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
A/Prof Glen Scholz glenms@unimelb.edu.au 9341 1545 Personal web page

Summary You will use cell culture systems and gene knockout mice to investigate how IL-36G prevents infection by viruses. The new knowledge you create will help us to develop better ways to treat diseases caused by viruses.

Project Details

The oral cavity is a major entry portal for important microbial pathogens, including viruses. We have demonstrated that the epithelial cells which line the oral cavity strongly express the novel inflammatory cytokine IL-36G when they detect the presence of microbes. Importantly, we have recently found that IL-36G stimulates epithelial cells to express genes that mediate antiviral responses. This suggests that IL-36G plays a role in preventing viral infection. In this project you will use cell culture systems and gene knockout mice to investigate how IL-36G prevents infection by viruses. The project will provide opportunities to develop skills in mammalian cell culture, manipulating gene expression, cytokine assays, analysis of cell signalling and gene expression, immunofluorescence confocal microscopy, critical thinking, scientific writing, and oral communication.



Faculty Research Themes

Infection and Immunology

School Research Themes

Oral Infection and Immunity



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Research Node

Royal Dental Hospital Melbourne,Bio21 Molecular Science and Biotechnology Institute

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