What do antibodies need to do to protect a woman against pregnancy-malaria?

Research Opportunity
Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Elizabeth Aitken elizabeth.aitken@unimelb.edu.au (03) 8344 1972 Personal web page

Summary This project will involve measuring complement binding antibodies towards placental malaria antigen using plate-based immunoassays in samples from pregnant women and/or individuals from Phase I vaccine trials, and analysing if they are protective or if they are generated.

Project Details

Pregnant women are susceptible to malaria and though we know which antigen women’s antibodies need to recognise, we don’t know the most efficient way for these antibodies to protect women. Antibodies may confer protection by interacting with complement. This project will involve measuring complement binding antibodies towards placental malaria antigen using plate-based immunoassays in samples from pregnant women and/or individuals from Phase I vaccine trials, and analysing if they are protective or if they are generated. This will help us identify the role of complement binding antibodies in protection, information needed to effectively design and evaluate a pregnancy-malaria vaccine.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

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