Vertical transmission of Ross River virus in mosquito vectors

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Julio Rodriguez-Andres julio.rodriguez@unimelb.edu.au 8880 8740 Personal web page
Co-supervisor Email Number Webpage
Professor John Fazakerley john.fazakerley@unimelb.edu.au (03) 9731 2261 Personal web page

Summary Using recombinant alphaviruses expressing fluorescent proteins, this project will look at aspects of the immune response in mosquitoes and the possibility that Ross River virus is transmitted vertically down the generations. Tools and techniques being used will include recombinant viruses, microscopy, cell culture and insect work.

Project Details

Alphaviruses such as Ross River virus, chikungunya and Semliki Forest virus are transmitted between susceptible vertebrate hosts by mosquito vectors. In vertebrates, these viruses initiate acute infections characterised by high virus production and brain or joint disease. In contrast, when a mosquito becomes infected, the virus establishes a persistent infection, there is no apparent effect on mosquito fitness and the mosquito transmits virus for the rest of its life.  Using recombinant alphaviruses expressing fluorescent proteins, this project will look at aspects of the immune response in mosquitoes and the possibility that virus is transmitted vertically down the generations. Tools and techniques being used will include recombinant viruses, microscopy, cell culture and insect work.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

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