Validating human transgenic mouse models for lupus therapeutics development
- Research Opportunity
- PhD, Masters by Research, Honours
- Department
- Microbiology and Immunology
- Location
- Doherty Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Fabienne Mackay | fabienne.mackay@unimelb.edu.au | (03) 8344 2726 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Dr William Figgett | william.figgett@unimelb.edu.au | (03) 8344 1589 | Personal web page |
Summary The project will utilise FACS, ELISA, microscopy, and ex vivo culture of B cell activation, to assess experimental therapy in the humanised and conventional mouse models of lupus.
Project Details
BAFF is a key survival factor for B cells yet excess BAFF can lead to autoimmune manifestations such as systemic lupus erythematosus (SLE), a disease with limited treatment options. We generated mice where the murine version of a new therapeutic target is replaced by a human version of the molecule. This project aims to evaluate the expression and activity levels of the humanised protein in these mice to validate the mice for preclinical therapeutics testing. Experimental treatments targeting the humanised protein will be tested for therapeutic effect. The project will utilise FACS, ELISA, microscopy, and ex vivo culture of B cell activation, to assess experimental therapy in the humanised and conventional mouse models of lupus.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department
Research Group / Unit / Centre
Mackay (F) laboratory: B lymphocytes, BAFF, autoimmunity and cancer
Research Node
Doherty InstituteMDHS Research library
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