Validating human transgenic mouse models for lupus therapeutics development

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Professor Fabienne Mackay fabienne.mackay@unimelb.edu.au (03) 8344 2726 Personal web page
Co-supervisor Email Number Webpage
Dr William Figgett william.figgett@unimelb.edu.au (03) 8344 1589 Personal web page

Summary The project will utilise FACS, ELISA, microscopy, and ex vivo culture of B cell activation, to assess experimental therapy in the humanised and conventional mouse models of lupus.

Project Details

BAFF is a key survival factor for B cells yet excess BAFF can lead to autoimmune manifestations such as systemic lupus erythematosus (SLE), a disease with limited treatment options. We generated mice where the murine version of a new therapeutic target is replaced by a human version of the molecule. This project aims to evaluate the expression and activity levels of the humanised protein in these mice to validate the mice for preclinical therapeutics testing. Experimental treatments targeting the humanised protein will be tested for therapeutic effect. The project will utilise FACS, ELISA, microscopy, and ex vivo culture of B cell activation, to assess experimental therapy in the humanised and conventional mouse models of lupus.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Mackay (F) laboratory: B lymphocytes, BAFF, autoimmunity and cancer

Research Node

Doherty Institute

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