Using high through-put genetic and metabolomic approaches to identify new drug targets in parasitic protozoa
- Department / Centre
- Biochemistry and Pharmacology
|Prof Malcolm McConvilleemail@example.com|
Summary The McConville group is interested in understanding how intracellular microbial pathogens, responsible for diseases such as malaria, human leishmaniasis and toxoplasmosis, are able to survive within their human/animal hosts and cause disease. We utilize advanced mass spectrometry approaches, as well as a range of biochemical and genetic techniques to identify microbial metabolic pathways that are switched on during infection and are essential for pathgenesis. We are also interested in identifying metabolic pathways in the host cell that are required for pathogenesis. These studies are directed at understanding fundamental aspects of microbial pathogenesis, as well as developing new anti-microbial or host-directed therapies for these important diseases.