Understanding traumatic brain injury

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Prof Peter Clark pcrack@unimelb.edu.au
Co-supervisor Email Number Webpage
Dr Juliet Taylor

Summary The Crack and Taylor group is run by Professor Peter Crack and Dr Juliet Taylor. The Neuropharmacology laboratory looks to understand how fundamental cellular signalling pathways can predispose the brain to exacerbated neurotrauma or neuropathology. In understanding how these pathways contribute to neural dysfunction we may be able to identify novel therapeutics that can be used to combat traumatic brain injury, Alzheimer’s disease and Parkinson’s disease.

Project Details

Traumatic brain injury (TBI) represents the major cause of death in young individuals in industrialised countries. Despite the improvement of neurosurgical procedures as well as critical care management, morbidity and mortality are still high and approximately 25% of these patients remain with permanent disabilities becoming a familiar, social and economic burden for society. A better understanding of events occurring in the brain after traumatic brain injury is essential to identify ways to limit the damage and ultimately improve the outcome. This project will focus on the role that neuroinflammation plays in the progression of neural injury after TBI. By altering the pathways that control neuroinflammation by either molecular or therapeutic means we are able to influence the outcome after TBI. The data generated by this project will be used to further understand the molecular pathways that are changed in the brain after TBI.
Skill acquisition: In vivo disease models, histology, immunohistochemistry, morphometry, quantitative PCR, FACS analysis of cell populations, cell and tissue culture, ELISA, molecular biology and western blotting.



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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