Understanding the role of the microbiome in chronic cardiovascular inflammation

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Dr Yung Chih Chen yungchih.chen@baker.edu.au
Co-supervisor Email Number Webpage
Prof Karlheinz Peter

Summary The Peter and Wang group focuses on basic and translational research covering a wide variety of themes, including cardiovascular disease, autoimmunity and cancer.

Project Details

The Peter and Wang group focuses on basic and translational research covering a wide variety of themes, including cardiovascular disease, autoimmunity and cancer. We study fundamental disease mechanisms in order to define the key cells and molecules which contribute to the development or outcome of disease. Using this information, we then design, test and implement novel molecular imaging approaches using state of the art technologies (magnetic resonance imaging, ultrasound, computed tomography, positron-emission tomography and 3D fluorescence emission computed tomography). We focus on novel therapeutic approaches, such as biological therapies targeting immune cells; and theranostics, which combine both therapeutics and diagnostics into a single platform. 

 

In recent years it has been demonstrated that the microbiome, composed of trillions of microbes inhabiting our bodies, can significantly influence disease susceptibility and severity. Mechanistically, the microbiome has been shown to elicit this influence by regulating metabolism and the immune system. Atherosclerosis is a disease of chronic inflammation and metabolic dysfunction, however, whether the microbiome plays a role in determining an individual's susceptibility to atherosclerosis or the disease's severity is unknown. This project will explore the role of the microbiome in the development of atherosclerosis with a key focus on how the microbiome influences the immune system. In addition, this research will define and test strategies for the therapeutic manipulation of the microbiome in the context of atherosclerosis and chronic inflammation. 




Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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