Understanding the role of MAIT cells in protection from microbial infections

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Sidonia Eckle seckle@unimelb.edu.au (03) 8344 0775 Personal web page
Co-supervisor Email Number Webpage
Dr Zhenjun Chen zhenjun@unimelb.edu.au (03) 8344 9910 Personal web page
Dr Alexandra Corbett corbetta@unimelb.edu.au (03) 8344 9914 Personal web page

Summary In collaboration with microbiologists and clinicians we have set up a number of infection models in mice relevant to human diseases. By comparing the pathogen burden in Mucosal-associated invariant T (MAIT) cell deficient versus competent mice we determine in each model whether MAIT cells are protective.

Project Details

There are very few studies that have investigated the role of MAIT cells in protection to microbial infections. In collaboration with microbiologists and clinicians we have set up a number of infection models in mice relevant to human diseases. By comparing the pathogen burden in MAIT cell deficient versus competent mice we determine in each model whether MAIT cells are protective. Using MAIT cell specific tetramers, developed originally in our laboratory, we characterise the frequency and function of MAIT cells by a range of flow cytometry-based techniques. Pathogenesis is assessed by histology. Such analysis provides an insight in the underlying mechanisms of protection, which are also determined in protection experiments with mice knocked-out for specific immune mediators. Microbial infection models include viral, bacterial and fungal pathogens. They are also complemented with human in vitro models of infection and where possible with experiments on samples from patients. As part of this project it is possible to focus only on human in vitro models of infection (and patient samples) or mouse work.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

McCluskey laboratory: Role of MAIT cells in health and disease

Research Node

Doherty Institute

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