Understanding the role of MAIT cells in immune-mediated pathology

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Sidonia Eckle seckle@unimelb.edu.au (03) 8344 0775 Personal web page
Co-supervisor Email Number Webpage
Dr Lars Kjer-Nielsen lars.kjer@unimelb.edu.au 8344 9910
Dr Alexandra Corbett corbetta@unimelb.edu.au (03) 8344 9914 Personal web page

Summary Based on in vitro stimulation assays with the relevant metabolites in healthy donors and patient samples, we seek to establish if mucosal-associated invariant T (MAIT) cells can mediate allergic reactions.

Project Details

There are very few studies that have definitively determined a role for MAIT cells in immune pathologies, such as allergies and inflammatory diseases. We have previously identified drug metabolites that stimulate MAIT cells and now want to understand if drug and other metabolites cause hypersensitivities, allergies or inflammatory conditions. In collaboration with clinicians we have access to samples from several cohorts of patients. Based on in vitro stimulation assays with the relevant metabolites in healthy donors and patient samples, we seek to establish if MAIT cells can mediate allergic reactions. This also builds on the lab’s previous work in drug hypersensitivities mediated by conventional T cells. Human clinical data will be complemented with in vitro human cell line model systems and potentially characterisation of the TCR recognition event at a molecular level using surface plasmon resonance and X-ray crystallography, together with collaborators.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

McCluskey laboratory: Role of MAIT cells in health and disease

Research Node

Doherty Institute

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