Understanding the Molecular Consequences of Mutations
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Biochemistry and Molecular Biology
- Bio21 Molecular Science and Biotechnology Institute
|Dr David Ascher David Ascherfirstname.lastname@example.org||+61390354794||Personal web page|
Summary We are continuously looking to expand and further develop our computational mutational analysis platform.
New computational models and learning algorithms
We are evaluating and validating new computational models for representing a mutation, as well as new machine learning algorithms (genetic programming and neural networks/deep learning) to build robust, efficient and effective predictive models of the various consequences of protein mutations.
Sequence and evolutionary information
In addition the the structural information used in our predictive platform, we are also including sequence and evolutionary information in order to better analyse the effects of mutations that alter post-translational modification and localisation, and those mutations within disordered regions which, while often lack detailed structural information, play very important roles in protein interactions. Ultimately we would also like to be able to predict the effects of mutations based upon protein sequence.
Proteins are dynamic molecules, and we have shown previously that how mutations alter the equilibrium between different conformations is important for understanding their role in disease and drug resistance. To address this we are using a combination of structural ensembles and coarse grained molecular dynamics to present a picture of the mutational effects across its conformational states.
To date, ours and others methods have focused on understanding the effects of single point missense mutations. However using a simulated thermodynamic cycle, we are developing methods able to predict the effects of more complex mutations including insertions, deletions, alternative splicing events, multiple point mutations and heterozygous mutations.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research Group / Unit / Centre
Research NodeBio21 Molecular Science and Biotechnology Institute
MDHS Research library
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