Understanding the formation and secretion of mitochondria-derived vesicles

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
Number of Master Places Available
Primary Supervisor Email Number Webpage
Dr Magdalene Montgomery magdalene.montgomery@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Paula Miotto

Summary Our group is interested in understanding the development of diabetic heart disease, with a particular focus on changes in mitochondrial function within the heart. We aim to define the metabolic pathways that drive cardiac mitochondrial dysfunction, with the longterm goal to identify new therapeutic angles for the treatment of heart disease.

Project Details

We made the novel discovery that the diabetic heart secretes mitochondrial components within vesicles as a means to dispose of damaged proteins and lipids. This project will assess the endocrine (i.e. secretory) function of the heart, with a focus on the formation and secretion of such mitochondria-derived vesicles (MDV). In addition, this project will investigate the systemic metabolic impact of these MDV in peripheral tissues.

Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

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