Understanding the effects of NASH-secreted factors on glucose and lipid metabolism

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Primary Supervisor Email Number Webpage
Dr Magdalene Montgomery magdalene.montgomery@unimelb.edu.au Personal web page

Summary One major focus of our group is to understand how the liver contributes to metabolic disease - ie. obesity, glucose intolerance and insulin resistance. Non-alcoholic fatty liver disease (NAFLD, fat accumulation in the liver) is found in 70% of obese individuals, with up to 30% of those further progressing to the more severe disease state - non-alcoholic steatohepatitis (NASH). NASH is characterized by liver steatosis and inflammation, hepatocyte ballooning and significant fibrosis. We aim to understand what proteins a NAFLD/NASH liver secretes and if these proteins contribute to changes in systemic metabolism (Can a fatty liver drive type 2 diabetes?).

Project Details

In a high-throughput screen we identified several proteins whose secretion was increased in the presence of NASH and we now aim to determine if these proteins affect (1) glucose metabolism and glycaemic control, (2) insulin sensitivity and (3) lipid metabolism in the key peripheral tissues of metabolism, including skeletal muscle, liver, adipose tissue and the pancreas

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