Understanding the biochemical basis of motor neurone disease

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
2
Primary Supervisor Email Number Webpage
A/Prof Peter Crouch pjcrouch@unimelb.edu.au
Co-supervisor Email Number Webpage
Dr James Hilton

Summary The focus of our research is to elucidate the biochemical basis of human disease. We study degenerative conditions of the central nervous system as well as a diverse range of cancers, and our overarching aim is to generate the information needed to help develop and test new therapeutic options and to improve patient outcomes through enhanced disease detection and characterisation. Recent significant achievements include bench-to-clinic translation of a new drug for motor neurone disease and a first of its kind method for imaging cancer.

Project Details

Our team has identified an important biochemical change that occurs in tissue afflicted with motor neurone disease, a fatal disorder of the central nervous system for which effective treatments do not yet exist.  Moreover, we have demonstrated that therapeutically targeting this change is protective, and our drug is now in the initial stages of clinical testing.  However, a better understanding of how this biochemical change relates to the decline of functional motor neurones is still required.  We are therefore examining changes to the abundance and functionality of specific proteins which we can relate to what we currently know about the drug's mechanism of action.  An increased understanding of these mechanisms will advance our understanding of the causes of motor neurone disease and also the opportunity for additional therapeutic intervention.



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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