Understanding glycogen dysregulation in diabetic heart failure

Research Opportunity
PhD students, Master of Biomedical Science
Number of Master Places Available
Primary Supervisor Email Number Webpage
Dr Lea Delbridge lmd@unimelb.edu.au

Summary The Cardiac Phenomics Laboratory research is about understanding how the heart response to stress can be managed to minimize the damaging impacts of a variety of disease conditions. We investigate responses of the working ‘pumping’ heart, of specialized muscle tissues and cells from different regions of the heart and of molecular signaling processes. As our name suggests, we look at how the cardiac ‘genome’ (the genetically defined heart) is translated in different stressor situations to create the ‘phenome’ (the structurally and functionally defined heart).

Project Details

Globally, diabetes is an epidemic disease with a specific cardiopathology independent of associated cardiovascular risk profiles. Diabetic hearts are more vulnerable to developing failure, especially after a myocardial infarct. Our work focuses on understanding the metabolic and structural changes leading to both diastolic and systolic dysfunction, examining how circulating glucose and insulin impacts on cardiopathology and identifying potential molecular targets for intervention. This project will utilise experimental models of type 1 and type 2 diabetes to
investigate the molecular and structural adaptations in the diabetic heart. We use cutting edge gene delivery and gene editing tools to create boutique experimental models of disease.

Research Opportunities

PhD students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

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