Understanding essential gene regulation in Staphylococcus aureus

Research Opportunity
PhD students, Masters by Research, Honours students
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Microbiology and Immunology
Primary Supervisor Email Number Webpage
Professor Tim Stinear tstinear@unimelb.edu.au 8344 5693 Personal web page
Co-supervisor Email Number Webpage
Dr Ian Monk

Summary Our laboratory has been investigating the molecular mechanism of WalKR function through the application of next generation DNA sequencing technologies such as RNAseq, ChIPseq, TNseq targeted mutagenesis and suppressor mutant screens. This project will apply the above techniques to determine the molecular basis of WalKR essentiality.

Project Details

Two component systems (TCS) enable bacteria to respond rapidly to the host environment. Among the 16 TCS in Staphylococcus aureus, only WalKR is essential, with clinical treatment failure linked to mutations within WalKR (leads to vancomycin resistance). Our laboratory has been investigating the molecular mechanism of WalKR function through the application of next generation DNA sequencing technologies such as RNAseq, ChIPseq, TNseq targeted mutagenesis and suppressor mutant screens. This project will apply the above techniques to determine the molecular basis of WalKR essentiality.



Faculty Research Themes

School Research Themes

Infection & Immunity



Research Opportunities

PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Microbiology and Immunology


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