Understanding essential gene regulation in Staphylococcus aureus
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Number of Honour Places Available
- 1
- Number of Master Places Available
- 1
- Department / Centre
- Microbiology and Immunology
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Tim Stinear | tstinear@unimelb.edu.au | 8344 5693 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Ian Monk |
Summary Our laboratory has been investigating the molecular mechanism of WalKR function through the application of next generation DNA sequencing technologies such as RNAseq, ChIPseq, TNseq targeted mutagenesis and suppressor mutant screens. This project will apply the above techniques to determine the molecular basis of WalKR essentiality.
Project Details
Two component systems (TCS) enable bacteria to respond rapidly to the host environment. Among the 16 TCS in Staphylococcus aureus, only WalKR is essential, with clinical treatment failure linked to mutations within WalKR (leads to vancomycin resistance). Our laboratory has been investigating the molecular mechanism of WalKR function through the application of next generation DNA sequencing technologies such as RNAseq, ChIPseq, TNseq targeted mutagenesis and suppressor mutant screens. This project will apply the above techniques to determine the molecular basis of WalKR essentiality.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
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