Treating the person not the disease

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Department
Biochemistry and Molecular Biology
Location
Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
Dr David Ascher david.ascher@unimelb.edu.au +61390354794 Personal web page

Project Details

We have developed a range of computational tools to deconvolute the molecular mechanisms of a mutation giving rise to different phenotypes. In collaboration with clinical partners we have shown that even though patients may present the same disease, they may arise from many different mutations that alter a patient’s outcome or how they may respond to a particular treatment. By analysing these mutations and predicting their effects on protein structure and function we are trying to revolutionise treatment strategies, an important step towards personalised medicine. We are currently working on a range of diseases including genetic diseases (Alkaptonuria, Urea cycle disorders, VHL), cancer (renal carcinomas), and drugvaccine resistance (TB, cancer, malaria, HIV, influenza). These projects combine both computational (bioinformatics) and experimental (protein expression, biophysics, structural biology) approaches to unravel the molecular mechanisms driving these mutations and derive novel predictive methods. This information is then used to help identify and guide the development of novel therapies to treat these conditions. One of the ultimate goals of these projects will be the development of webservers enabling the rapid analysis of mutations to help guide clinical decisions.


School Research Themes

Molecular Mechanisms of Disease, Systems Biology



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Biochemistry and Molecular Biology

Research Group / Unit / Centre

Ascher laboratory: Structural biology and bioinformatics

Research Node

Bio21 Molecular Science and Biotechnology Institute

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