The role of the prorenin receptor in male and female infertility

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Dr Dagmar Wilhelm dagmar.wilhelm@unimelb.edu.au
Co-supervisor Email Number Webpage
Dr Dan Bird

Summary The ultimate goal of our research is to understand the genetics of sex determination and gonad development, and how failure results in human disorders of sex development and infertility. Disorders/differences of sex development (DSDs) refer to congenital conditions in which the development of chromosomal, gonadal or anatomical sex is atypical. They are very common, with an estimate of approximately 1 in 4,500 births. They have profound psychological and reproductive consequences for the patient, which are also often prone to testicular or ovarian cancer later in life. Surprisingly, although many genes have been identified which play a role in these processes for almost 70% of cases that we still do not know the underlying cause. Clearly, the identification of new genes and regulatory mechanisms involved in the formation of testis and ovary is critical for understanding the molecular pathology of DSDs.

Project Details

The prorenin receptor is best known for its role in the renin-angiotensin system (RAS). However, recent research also shows that it plays multiple roles independent of pro/renin binding. We have shown that loss of the prorenin receptor in mouse somatic cells of the gonads results in male and female infertility. This project characterizes its role in fertility using mouse and Drosophila as model systems.



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


MDHS Research library
Explore by researcher, school, project or topic.