The role of the prion protein in brain cancer
- Research Opportunity
- Masters by Research, Honours
- Department
- Microbiology and Immunology
- Location
- Doherty Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Associate Professor Vicki Lawson | vlawson@unimelb.edu.au | Personal web page |
Summary This project will involve breeding and selection (genotyping) of mice, induction of glioblastoma, monitoring of mice for signs of disease and analysis of tissue for evidence of disease.
Project Details
Recent studies have reported that the cellular form of the prion protein is upregulated in several cancer types and has been associated with disease progression and poor treatment response. This project will investigate the role of the prion protein in cancer using a mouse model of glioblastoma in which PrPC expression has been ablated. This project will involve breeding and selection (genotyping) of mice, induction of glioblastoma, monitoring of mice for signs of disease and analysis of tissue for evidence of disease. Adult neural stem cells will be derived from this mouse model to enable in vitro (cell culture) characterisation of the cells that give rise to glioblastoma and the contribution of PrPC expression on cancer specific processes.
Faculty Research Themes
School Research Themes
Research Opportunities
Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department
Research Group / Unit / Centre
Lawson laboratory: Neurodegenerative disease caused by prions
Research Node
Doherty InstituteMDHS Research library
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