The role of the prion protein in brain cancer

Research Opportunity
Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Associate Professor Vicki Lawson vlawson@unimelb.edu.au Personal web page

Summary This project will involve breeding and selection (genotyping) of mice, induction of glioblastoma, monitoring of mice for signs of disease and analysis of tissue for evidence of disease.

Project Details

Recent studies have reported that the cellular form of the prion protein is upregulated in several cancer types and has been associated with disease progression and poor treatment response. This project will investigate the role of the prion protein in cancer using a mouse model of glioblastoma in which PrPC expression has been ablated. This project will involve breeding and selection (genotyping) of mice, induction of glioblastoma, monitoring of mice for signs of disease and analysis of tissue for evidence of disease. Adult neural stem cells will be derived from this mouse model to enable in vitro (cell culture) characterisation of the cells that give rise to glioblastoma and the contribution of PrPC expression on cancer specific processes.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Lawson laboratory: Neurodegenerative disease caused by prions

Research Node

Doherty Institute

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