The role of mast cell-derived macrophage migration inhibitory factor (MIF) in Alzheimer’s disease

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Dr Graham Mackay gmackay@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Prof Peter Crack

Summary Our team is focussed largely around the fascinating mast cell and its role in allergic and non-allergic disease. In particular, we want to better understand how these cells are activated, the mediators they release and if we can translate this knowledge to generating new therapeutics.

Project Details

Macrophage migratory inhibitor factor (MIF) is a multi-functional cytokine that has both intracellular and extracellular actions and possesses enzymatic activity alongside the ability to stimulate its receptor. In this project you will examine the stimulus-induced release of MIF from immune cells that are thought to play an important role in Alzheimer’s disease (AD) pathology, with a focus on the mast cell. You will also examine the expression of MIF in samples taken from animal models of AD and from patients with the disease. Combined, the project will lead to a better understanding of the role of MIF in driving the inflammatory neurodegeneration observed in AD. 



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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