The role of glucose metabolism in the regulation of immunity
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Department / Centre
- Microbiology and Immunology
- Location
- Doherty Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Jose Villadangos | j.villadangos@unimelb.edu.au | (03) 9035 7684 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Nishma Gupta | guptan@unimelb.edu.au | 9035 7698 |
Summary We are characterising the function of O-GlcNAc glycosylation in immune cells by identifying changes in patterns of glycosylation in different metabolic states and upon encounter of pathogens.
Project Details
O-GlcNAc glycosylation involves addition of a single sugar, β-N-acetylglucosamine, to serine or threonine residues of proteins. It is a unique type of glycosylation found on nuclear and cytoplasmic proteins. The addition and removal of O-GlcNAc is catalysed by O-GlcNAc transferase (OGT) and O-GlcNAse (OGA) respectively. It is a reversible modification akin to phosphorylation. Indeed, O-GlcNAc glycosylation occurs in dynamic interplay with phosphorylation, either on the same or adjacent residues. The cross-talk between these two modifications in turn regulates various cellular processes. We are characterising the function of O-GlcNAc glycosylation in immune cells by identifying changes in patterns of glycosylation in different metabolic states and upon encounter of pathogens. The function of glycosylated proteins will be further studied to understand the relevance of their O-GlcNAc status in various immune cell activities.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Group / Unit / Centre
Research Node
Doherty InstituteMDHS Research library
Explore by researcher, school, project or topic.