The role of glucose metabolism in the regulation of immunity

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Professor Jose Villadangos j.villadangos@unimelb.edu.au (03) 9035 7684 Personal web page
Co-supervisor Email Number Webpage
Dr Nishma Gupta guptan@unimelb.edu.au 9035 7698

Summary We are characterising the function of O-GlcNAc glycosylation in immune cells by identifying changes in patterns of glycosylation in different metabolic states and upon encounter of pathogens.

Project Details

O-GlcNAc glycosylation involves addition of a single sugar, β-N-acetylglucosamine, to serine or threonine residues of proteins. It is a unique type of glycosylation found on nuclear and cytoplasmic proteins. The addition and removal of O-GlcNAc is catalysed by O-GlcNAc transferase (OGT) and O-GlcNAse (OGA) respectively. It is a reversible modification akin to phosphorylation. Indeed, O-GlcNAc glycosylation occurs in dynamic interplay with phosphorylation, either on the same or adjacent residues. The cross-talk between these two modifications in turn regulates various cellular processes. We are characterising the function of O-GlcNAc glycosylation in immune cells by identifying changes in patterns of glycosylation in different metabolic states and upon encounter of pathogens. The function of glycosylated proteins will be further studied to understand the relevance of their O-GlcNAc status in various immune cell activities.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Villadangos laboratory: Antigen presenting cells & molecules that initiate T cell immunity against pathogens and cancer

Research Node

Doherty Institute

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