The connection between motor neurone disease and progressive multiple sclerosis

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
2
Primary Supervisor Email Number Webpage
A/Prof Peter Crouch pjcrouch@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr James Hilton

Summary The focus of our research is to elucidate the biochemical basis of human disease. We study degenerative conditions of the central nervous system as well as a diverse range of cancers, and our overarching aim is to generate the information needed to help develop and test new therapeutic options and to improve patient outcomes through enhanced disease detection and characterisation. Recent significant achievements include bench-to-clinic translation of a new drug for motor neurone disease and a first of its kind method for imaging cancer.To achieve these outcomes, we utilise a broad range of experimental paradigms, ranging from cells grown in culture through to direct examination of human tissue. Our analytical approaches span fundamental techniques (enzyme activity assays, gene expression analysis, histology and western blotting) through to highly sophisticated techniques such as quantitative in situ elemental imaging .

Project Details

Significant similarities exist between motor neurone disease and progressive forms of multiple sclerosis.  In pursuing our motor neurone disease research, we established that some of the similarities with progressive multiple sclerosis may represent opportunity for therapeutic intervention.  We have therefore been examining tissue samples from people who had progressive multiple sclerosis and also from models of the disease.  We are using the information we have generated from our motor neurone disease research to guide these analyses.  More extensive analysis of multiple sclerosis tissue is needed to help us consolidate the connection between the two diseases and therefore to further assess the opportunity to treat the two using a single therapeutic strategy.



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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