The bioinformatic analysis of neuroinflammatory pathways seen in alzheimers and parkinsons disease

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Prof Peter Clark pcrack@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Juliet Taylor
Dr Victoria Perreau

Summary The Crack and Taylor group is run by Professor Peter Crack and Dr Juliet Taylor. The Neuropharmacology laboratory looks to understand how fundamental cellular signalling pathways can predispose the brain to exacerbated neurotrauma or neuropathology. In understanding how these pathways contribute to neural dysfunction we may be able to identify novel therapeutics that can be used to combat traumatic brain injury, Alzheimer’s disease and Parkinson’s disease.

Project Details

Neuroinflammation is increasingly being attributed to the causation and exacerbation of both acute and chronic neuropathologies. The emerging field of bioinformatics will be used to identify proteins and signal transduction pathways that contribute to the production of neuroinflammation. This project be largely in silico based and will utilize the skills that are provided by the core bioinformatics facility located in the Melbourne Brain Centre under the guidance of Dr Victoria Perreau. This approach enables hypothesis generation through leverage of genomic, transcriptomic, phenotypic and proteomic datasets to understand complex systems. The student will focus on understanding complex interplay of signal transduction networks that control the neuroinflammatory response.
Skill acquisition: Bioinformatics, systems biology, pathway analysis.

Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

MDHS Research library
Explore by researcher, school, project or topic.