Testing a novel strategy to target chronic lymphocytic leukemia

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Professor Fabienne Mackay fabienne.mackay@unimelb.edu.au (03) 8344 2726 Personal web page
Co-supervisor Email Number Webpage
Dr Simona Infantino simonai@unimelb.edu.au 8344 1589

Summary This project aims to test whether targeting TACI in a model of CLL will be effective at restoring immunocompetency. Flow cytometry, ELISA, in vitro assays and others will be used throughout the project.

Project Details

Chronic Lymphocytic Leukemia (CLL) is a B cell malignancy that is the most common cause of leukemia in adults aged over 65. Recent studies have shown that CLL cells produce IL-10, an immunosuppressive cytokine that helps the cancer cells evade the immune system by shutting down anti-tumor immunity. New exciting data from our lab shows that IL-10 production by CLL cells is triggered by BAFF, a TNF-like cytokine critical for B cell maturation and survival that is implicated in the development and progression of CLL. Preliminary data show that BAFF-driven IL-10 production by CLL cells is mediated via the receptor TACI, as TACI inhibition resulted in attenuated IL-10 secretion. This project aims to test whether targeting TACI in a model of CLL will be effective at restoring immunocompetency. Flow cytometry, ELISA, in vitro assays and others will be used throughout the project.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Mackay (F) laboratory: B lymphocytes, BAFF, autoimmunity and cancer

Research Node

Doherty Institute

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