Synergistic and antagonistic interplay between Streptococcus pneumoniae and respiratory viruses

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Associate Professor Catherine Satzke catherine.satzke@mcri.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Sam Manna

Summary The contribution of bacterial-viral co-infections to the onset and severity of disease is increasingly attracting interest from researchers globally. Specifically, it is well established that co-infections of Streptococcus pneumoniae with respiratory viruses (e.g. influenza or respiratory syncytial virus) impact the severity of acute respiratory infections.

Project Details

The contribution of bacterial-viral co-infections to the onset and severity ofdisease is increasingly attracting interest from researchers globally. Specifically, it is well established that co-infections of Streptococcus pneumoniae with respiratory viruses (e.g. influenza or respiratory syncytial virus) impact the severity of acute respiratory infections. This is because viral replication creates a more hospitable environmentfor pathogenic bacteria of the respiratory tract to flourish, predisposingindividuals to a bacterial superinfection. However, recent research has foundthat the interplay between pneumococci and viruses is more complex thanpreviously anticipated. We and others have shown that some aspects ofco-infection are synergistic (resulting in greater disease severity), whileothers are antagonistic, where the presence of one pathogen negatively impactsthe other. In this project, you will elucidate the underlying microbiological and/or immunological mechanisms that govern the synergistic and antagonisticaspects of the interplay between pneumococci and respiratory viruses. Keyapproaches to this project include working with in vivo models as well as microbiological and immunologicalanalysis of tissues from the respiratory tract. Your work will help usunderstand the complexities of pneumococcal-viral co-infection, including theirimplications for the effectiveness of vaccines targeting these pathogens.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

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