Stem cell therapy to treat Hirschsprung's disease
- Research Opportunity
- PhD students, Honours students, Master of Biomedical Science
- Number of Honour Places Available
- Number of Master Places Available
|Dr Lincon Stampfirstname.lastname@example.org|
|Dr Marlene Haoemail@example.com|
|A/Prof Sebastian King|
Summary Our group is interested in the development of the enteric nervous system and stem cell therapies for enteric neuropathies. The enteric nervous system is responsible for the co-ordinated control of gut function. Enteric neurons and glia are located in a network of interconnecting ganglia within the wall of the gastrointestinal tract. Correct development of this nervous system is crucial for proper control of digestive function. Please refer to our website for more information on our research and publications:
Hirschsprung's Disease arises from the failure of neural crest cells to migrate to the anal end of the colon, resulting in a lack of enteric neurons in the unpopulated region. As the enteric nervous system is crucial for gastrointestinal function, there is no propulsive activity in the aganglionic region and there is a build-up of gut contents, which can prove fatal if left untreated. Hirschsprung patients currently undergo "pull-through" surgery to remove the aganglionic region of bowel. Whilst this is life-saving, most patients suffer chronic, long-term complications, including constipation, faecal soiling, and associated psychosocial problems.
PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
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