Role of suppressor of cytokine signalling proteins in viral encephalitis
- Research Opportunity
- PhD, Masters by Research, Honours
- Department
- Microbiology and Immunology
- Location
- Doherty Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Lukasz Kedzierski | lukaszk@unimelb.edu.au | (03) 8344 0502 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Professor John Fazakerley | john.fazakerley@unimelb.edu.au | (03) 9731 2261 | Personal web page |
Summary The suppressor of cytokine signalling (SOCS) proteins are key negative regulators of the JAK-STAT pathway and are responsible for controlling cytokine networks involved in immune response and inflammation. This project aims to explore the role of SOCS4 or SOCS5 during SFV induced encephalitis in a mouse model.
Project Details
The suppressor of cytokine signalling (SOCS) proteins are key negative regulators of the JAK-STAT pathway and are responsible for controlling cytokine networks involved in immune response and inflammation. SOCS are expressed in the central nervous system (CNS) and have the potential to modulate immune responses in the brain. We have recently shown that SOCS4- and SOCS5-deficient mice have different susceptibility phenotypes to an alphavirus infection, that virus RNA persists in the brain, and that infectious virus can be reactivated following immunosuppression. This project aims to explore the role of SOCS4 or SOCS5 during SFV induced encephalitis in a mouse model.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department
Research Node
Doherty InstituteMDHS Research library
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