Role of O-linked glycosylation system across the Burkholderia genus
- Research Opportunity
- PhD, Masters by Research, Honours
- Microbiology and Immunology
- Doherty Institute
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Summary The goal of this project is to understand the role, diversity and machinery responsible for glycosylation in Bukholderia species.
Protein glycosylation, the chemical addition of sugars to proteins, is an important but poorly understood aspect of bacterial physiology. Within the Burkholderia genus, we have discovered a highly conserved O-linked glycosylation system. The conservation of this system across pathogenic and non-pathogenic species suggests that glycosylation plays a far more fundamental role in the physiology of Bukholderia than previously thought. The goal of this project is to understand the role, diversity and machinery responsible for glycosylation in Bukholderia species. By studying glycosylation within Burkholderia we aim to gain a fundamental understanding of this biological processes and how it contributes to bacterial survival. The long-term goal of this project is to learn how we can target protein glycosylation to generate new antimicrobial agents, and how we can exploit bacterial glycosylation systems to generate novel glycoconjugates such as vaccines.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research NodeDoherty Institute
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