Role of O-linked glycosylation system across the Burkholderia genus

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Nichollas Scott nichollas.scott@unimelb.edu.au (03) 8344 6724 Personal web page

Summary The goal of this project is to understand the role, diversity and machinery responsible for glycosylation in Bukholderia species.

Project Details

Protein glycosylation, the chemical addition of sugars to proteins, is an important but poorly understood aspect of bacterial physiology. Within the Burkholderia genus, we have discovered a highly conserved O-linked glycosylation system. The conservation of this system across pathogenic and non-pathogenic species suggests that glycosylation plays a far more fundamental role in the physiology of Bukholderia than previously thought. The goal of this project is to understand the role, diversity and machinery responsible for glycosylation in Bukholderia species. By studying glycosylation within Burkholderia we aim to gain a fundamental understanding of this biological processes and how it contributes to bacterial survival. The long-term goal of this project is to learn how we can target protein glycosylation to generate new antimicrobial agents, and how we can exploit bacterial glycosylation systems to generate novel glycoconjugates such as vaccines.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

MDHS Research library
Explore by researcher, school, project or topic.