RNA control of HIV latency

Research Opportunity
PhD, Masters by Research, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Microbiology and Immunology
Primary Supervisor Email Number Webpage
Professor Damian Purcell dfjp@unimelb.edu.au 8344 6753 Personal web page

Summary This project studies these chimeric host-HIV mRNAs and investigates a folded RNA-element that underlies Tat coding RNA, its RNA-epigenetic modifications and the cellular protein binding partners that function to permit Tat-expression through a privileged IRES-translation pathway to regulate HIV-latency.

Project Details

Long-lived CD4+ T cells harbouring integrated copies of HIV proviral DNA stand as the barrier to sustained HIV remission without ongoing antiretroviral drug therapy. Multiple mechanisms restrict the viral gene expression needed for immune-detection and clearance. However, RNA transcription from the adjacent highly-active cellular gene reads-through into provirus, whereupon mRNA splicing and other mechanisms recombine HIV Tat RNA into mature cellular RNAs. This project studies these chimeric host-HIV mRNAs and investigates a folded RNA-element that underlies Tat coding RNA, its RNA-epigenetic modifications and the cellular protein binding partners that function to permit Tat-expression through a privileged IRES-translation pathway to regulate HIV-latency.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Purcell laboratory: Viral RNA elements, regulation of HIV replication, HIV antibody vaccine


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