Rebuilding the brain after stroke

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Dr Lachlan Thompson lachlant@unimelb.edu.au
Co-supervisor Email Number Webpage
Dr Jennifer Hollands

Summary Our laboratory is interested in the idea that stem cells can repair the damaged brain. There are two broad strategies we are pursuing. The first is neural transplantation. It is an approach that has had some success clinically for Parkinson’s disease and involves the transplantation of new neurons directly into the patient’s brain in order to functionally compensate for those lost to the disease. We are continuing to explore and optimise this as a therapeutic option not only for Parkinson’s disease but also for other neurological conditions such as stroke and motor neuron disease. The second strategy is based on the idea that the brain retains some capacity for ‘self-repair’ through neurogenesis. Part of our research program seeks to characterise the brain’s own capacity to generate new neurons in response to injury and to manipulate this response in favour of therapeutic outcomes

Project Details

Pluripotent stem cells can be used to generate a wide variety of neuronal subtypes relevant for repair of the central nervous system. Recently we showed that cortical neurons can be transplanted into the part of the cortex damaged by a focal stroke and have a remarkable capacity to integrate into the existing host circuitry in order to restore motor function. This project will extend on these findings in order to explore whether we can restore multiple circuits in more severe models of stoke affecting multiple brain region by transplanting multiple neuronal cell types. The project will utilise a number of in vitro and in vivo techniques including: human pluripotent cell culture; immunochemistry; stereotaxic surgery; analysis of animal behaviour; histology and microscopy.



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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