Protein trafficking and cellular architecture

Research Opportunity
PhD, Masters by Research, Honours
Department
Biochemistry and Molecular Biology
Location
Bio21 Molecular Science and Biotechnology Institute
Primary Supervisor Email Number Webpage
Professor Leann Tilley ltilley@unimelb.edu.au 0383442227 Personal web page

Project Details

Electron tomography of the malaria parasite

Electron tomography of the malaria parasite The malaria parasite spends part of its life-cycle inside the erythrocytes of its human host. The parasite modifies the erythrocyte to promote its own growth and survival. To do so, the intracellular parasite has to export proteins beyond the boundaries of its own plasma membrane. The molecular machinery and the mechanisms of transport involved in the external transport system are not yet understood, although it appears that the signals directing trafficking in the malaria parasite differ from those in mammalian systems.

Characterisation of the components of the secretory pathway in the malaria parasite may lead to the development of novel antimalarial strategies. Prof Tilley's laboratory uses cell biology, transfection and imaging techniques to identify and characterise the parasite components responsible for the unusual trafficking events and the sequences in exported polypeptides required for correct trafficking. Electron tomography of the malaria parasite, Plasmodium falciparum. The rendered model shows the parasite and its exomembrane system in the host red blood cell



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Cellular Imaging & Structural Biology



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Biochemistry and Molecular Biology

Research Group / Unit / Centre

Tilley laboratory: Measuring and modelling malaria parasites to develop new antimalarials

Research Node

Bio21 Molecular Science and Biotechnology Institute

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