Protein trafficking and cellular architecture
- Research Opportunity
- PhD, Masters by Research, Honours
- Department
- Biochemistry and Molecular Biology
- Location
- Bio21 Molecular Science and Biotechnology Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Leann Tilley | ltilley@unimelb.edu.au | 0383442227 | Personal web page |
Summary Electron tomography of the malaria parasite The malaria parasite spends part of its life-cycle inside the erythrocytes of its human host.
Project Details
The parasite modifies the erythrocyte to promote its own growth and survival. To do so, the intracellular parasite has to export proteins beyond the boundaries of its own plasma membrane. The molecular machinery and the mechanisms of transport involved in the external transport system are not yet understood, although it appears that the signals directing trafficking in the malaria parasite differ from those in mammalian systems.
Characterisation of the components of the secretory pathway in the malaria parasite may lead to the development of novel antimalarial strategies. Prof Tilley's laboratory uses cell biology, transfection and imaging techniques to identify and characterise the parasite components responsible for the unusual trafficking events and the sequences in exported polypeptides required for correct trafficking. Electron tomography of the malaria parasite, Plasmodium falciparum. The rendered model shows the parasite and its exomembrane system in the host red blood cell
Faculty Research Themes
School Research Themes
Infection & Immunity, Cellular Imaging & Structural Biology
Research Opportunities
PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department
Biochemistry and Molecular Biology
Research Group / Unit / Centre
Tilley laboratory: Measuring and modelling malaria parasites to develop new antimalarials
Research Node
Bio21 Molecular Science and Biotechnology InstituteMDHS Research library
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