Protective capacity of malaria-specific liver-tissue-resident memory T cells
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Department / Centre
- Microbiology and Immunology
- Location
- Doherty Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Lauren Holz | lauren.holz@unimelb.edu.au | 8344 0782 | Personal web page |
Summary This project will investigate which cell population in the liver re-activates malaria-specific tissue-resident memory T cells after challenge, and how the phenotype and behaviour of these cells changes after challenge.
Project Details
We have developed a glycolipid-peptide conjugate vaccine that provides sterile immunity against malaria. Protection in this model is absolutely dependent on malaria-specific tissue-resident CD8 T cells, but how these cells provide protection is not clear. This project will investigate which cell population in the liver re-activates malaria-specific tissue-resident memory T cells after challenge, and how the phenotype and behaviour of these cells changes after challenge. This project will use animal models in combination with advanced immunological techniques including flow cytometry, and intravital imaging.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Group / Unit / Centre
Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity
Research Node
Doherty InstituteMDHS Research library
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