Protective capacity of malaria-specific liver-tissue-resident memory T cells

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Lauren Holz lauren.holz@unimelb.edu.au 8344 0782 Personal web page

Summary This project will investigate which cell population in the liver re-activates malaria-specific tissue-resident memory T cells after challenge, and how the phenotype and behaviour of these cells changes after challenge.

Project Details

We have developed a glycolipid-peptide conjugate vaccine that provides sterile immunity against malaria. Protection in this model is absolutely dependent on malaria-specific tissue-resident CD8 T cells, but how these cells provide protection is not clear. This project will investigate which cell population in the liver re-activates malaria-specific tissue-resident memory T cells after challenge, and how the phenotype and behaviour of these cells changes after challenge. This project will use animal models in combination with advanced immunological techniques including flow cytometry, and intravital imaging.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity

Research Node

Doherty Institute

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