Preventing infections of the highly puke-ogenic virus - norovirus

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Professor Jason Mackenzie jason.mackenzie@unimelb.edu.au (03) 9035 8376 Personal web page
Co-supervisor Email Number Webpage
Professor Joe Torressi josepht@unimelb.edu.au (03) 8345 3262 Personal web page

Summary In this project we aim to utilise a vaccine development platform to generate virus-like particle of norovirus and determine their effectiveness in priming and providing a protective immune response to infection. The project will involve the design and production of the virus-like particles to be used in vaccination regimes.

Project Details

Norovirus infections results in a highly acute disease with symptoms that include explosive diarrhea and projectile vomiting. It is an infection that affects 700 million people each year and you are likely to get 4-5 infections over your lifetime. Yet there is no treatment or prevention options against this significant pathogen as efforts have been hampered by the inability to effectively cultivate the virus in laboratory conditions. In this project we aim to utilise a vaccine development platform to generate virus-like particle of norovirus and determine their effectiveness in priming and providing a protective immune response to infection. The project will involve the design and production of the virus-like particles to be used in vaccination regimes. Subsequently, the immune response generated to these particles will be assessed. We will also generate virus-like particles to the related mouse norovirus, providing us with an effective model to assess neutralisation and immune correlates, and a tool for us to isolate reactive memory B cells for antibody isolation.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

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