Preventing infections of the highly puke-ogenic virus - norovirus
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Department / Centre
- Microbiology and Immunology
- Location
- Doherty Institute
Primary Supervisor | Number | Webpage | |
---|---|---|---|
Professor Jason Mackenzie | jason.mackenzie@unimelb.edu.au | (03) 9035 8376 | Personal web page |
Co-supervisor | Number | Webpage | |
---|---|---|---|
Professor Joe Torressi | josepht@unimelb.edu.au | (03) 8345 3262 | Personal web page |
Summary In this project we aim to utilise a vaccine development platform to generate virus-like particle of norovirus and determine their effectiveness in priming and providing a protective immune response to infection. The project will involve the design and production of the virus-like particles to be used in vaccination regimes.
Project Details
Norovirus infections results in a highly acute disease with symptoms that include explosive diarrhea and projectile vomiting. It is an infection that affects 700 million people each year and you are likely to get 4-5 infections over your lifetime. Yet there is no treatment or prevention options against this significant pathogen as efforts have been hampered by the inability to effectively cultivate the virus in laboratory conditions. In this project we aim to utilise a vaccine development platform to generate virus-like particle of norovirus and determine their effectiveness in priming and providing a protective immune response to infection. The project will involve the design and production of the virus-like particles to be used in vaccination regimes. Subsequently, the immune response generated to these particles will be assessed. We will also generate virus-like particles to the related mouse norovirus, providing us with an effective model to assess neutralisation and immune correlates, and a tool for us to isolate reactive memory B cells for antibody isolation.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Node
Doherty InstituteMDHS Research library
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