Population genomics of endemic Streptococcus pyogenes

Summary Through linking genomics with epidemiology, we aim to examine the evolutionary relationship between disease causing Streptococcus pyogenes clones within remote communities of Australia. Furthermore, we will apply statistical genetic models to identify genetic signatures associated with different disease stats and/or tissue tropism.

Project Details

Streptococcus pyogenes is one of the leading infectious disease agents in the world. The disease burden is alarmingly high within the Top End of Australia where the epidemiology of infection contrasts that of other geographical regions. Through linking genomics with epidemiology, we aim to examine the evolutionary relationship between disease causing Streptococcus pyogenes clones within remote communities of Australia. Furthermore, we will apply statistical genetic models to identify genetic signatures associated with different disease stats and/or tissue tropism. Unlocking these mysteries is key to informing public health intervention strategies including the development of informed vaccine programs within disease endemic regions.