Pathogenesis of HTLV-1 subtype-C infecting remote indigenous Australians
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Number of Honour Places Available
- 1
- Number of Master Places Available
- 1
- Department
- Microbiology and Immunology
- Location
- Doherty Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Damian Purcell | dfjp@unimelb.edu.au | 8344 6753 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Paula Ellenberg |
Summary This project examines p12 and HBZ expression and function during HTLV-1c replication. The role of HTLV-1c provirus-accumulation and immune-dysfunction in diminished health outcomes for Indigenous central Australians will be explored using HTLV-1c integration-site mapping and T cell receptor clonotyping.
Project Details
The HTLV-1 subtype-C (HTLV-1c) is endemic in remote central Australian Indigenous communities with prevalence greater than 50 per cent. Austral-Melanesian HTLV-1c infections with a high proviral load are associated with immunopathogenic conditions, such as bronchiectasis. Sequences from 30 HTLV-1c genomes reveal significant differences in the HBZ and p12 coding-regions compared to the cosmopolitan subtype-A from Africa and Japan that is commonly associated with leukaemia and myelopathy. This project examines p12 and HBZ expression and function during HTLV-1c replication. The role of HTLV-1c provirus-accumulation and immune-dysfunction in diminished health outcomes for Indigenous central Australians will be explored using HTLV-1c integration-site mapping and T cell receptor clonotyping.
Faculty Research Themes
School Research Themes
Research Opportunities
PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department
Research Node
Doherty InstituteMDHS Research library
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