Pathogenesis of HTLV-1 subtype-C infecting remote indigenous Australians

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Professor Damian Purcell dfjp@unimelb.edu.au 8344 6753 Personal web page
Co-supervisor Email Number Webpage
Dr Paula Ellenberg

Summary This project examines p12 and HBZ expression and function during HTLV-1c replication. The role of HTLV-1c provirus-accumulation and immune-dysfunction in diminished health outcomes for Indigenous central Australians will be explored using HTLV-1c integration-site mapping and T cell receptor clonotyping.

Project Details

The HTLV-1 subtype-C (HTLV-1c) is endemic in remote central Australian Indigenous communities with prevalence greater than 50 per cent. Austral-Melanesian HTLV-1c infections with a high proviral load are associated with immunopathogenic conditions, such as bronchiectasis. Sequences from 30 HTLV-1c genomes reveal significant differences in the HBZ and p12 coding-regions compared to the cosmopolitan subtype-A from Africa and Japan that is commonly associated with leukaemia and myelopathy. This project examines p12 and HBZ expression and function during HTLV-1c replication. The role of HTLV-1c provirus-accumulation and immune-dysfunction in diminished health outcomes for Indigenous central Australians will be explored using HTLV-1c integration-site mapping and T cell receptor clonotyping.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

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