Ontogenetic activation of vagal afferents to decode viscerosensory signal processing within the brain.

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Dr Stuart McDougall stuart.mcdougall@florey.edu.au Personal web page
Co-supervisor Email Number Webpage
Prof Andrew Allen

Summary The McDougall/Viserosensory lab at the Florey Institute studies the basic neurophysiology underpinning the integration of sensory information within the brain. Our focus of study is at the level of the brain that first receives signals from visceral organs including those of the cardiorespiratory and gastrointestinal systems. This basic knowledge gained is pertinent to several disease states including; hypertension and obesity, and mental health. The primary techniques utilised within the laboratory revolve around anatomical mapping using viral tools in combination with in vitro slice electrophysiology. We possess a large skill-set and toolkit to answer a variety of experimental questions including optogenetics through to behavioural paradigms.

Project Details

Background: How different sensory signals from internal organs are organised and processed upon first entering the brain is ill defined. Viscerosensory signals arise from several functional modalities; baroreceptors, chemoreceptors, lung stretch afferents, gastrointestinal etc. These varied signals all terminate in the solitary nucleus with overlapping terminal fields. Project: You will use optogenetic tools, that allow for the selectively activation of vagal sensory neurons, to unravel how signals from these different sensory modalities ‘talk’ to the brain using in vito slice electrophysiology. Optogentic and electrical activation will be compared to further understand to functional determine how the local circuits are organised. This work will be highly relevant to current and future strategies to manipulation behaviour and/or autonomic function.



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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