New antibiotics from old bacteria

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Sacha Pidot sacha.pidot@unimelb.edu.au 9035 3129 Personal web page
Co-supervisor Email Number Webpage
Professor Tim Stinear tstinear@unimelb.edu.au 8344 5693 Personal web page

Summary This project will investigate the antibacterial activity of a diverse collection of 700 human pathogenic Actinobacteria held by our state microbiology reference laboratory, with the ultimate aim to identify new antimicrobials that can inhibit hospital superbugs, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. A combination of techniques will be used in this project, including genomics, molecular biology, biochemistry and mass spectrometry, to identify new antibiotics produced by this collection of bacteria.

Project Details

Development of new antibiotics is key to addressing the crisis in human health caused by the rise of multidrug resistant superbugs. Traditionally, soil-derived Actinobacteria, particularly the genus Streptomyces, are the most prolific antibiotic producers, however, high re-discovery rates of known compounds demand the testing of new reservoirs of biodiversity and bioactive molecules. Human-associated bacteria, including pathogenic bacteria, are a previously untapped source of antimicrobial diversity. This project will investigate the antibacterial activity of a diverse collection of 700 human pathogenic Actinobacteria held by our state microbiology reference laboratory, with the ultimate aim to identify new antimicrobials that can inhibit hospital superbugs, such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. A combination of techniques will be used in this project, including genomics, molecular biology, biochemistry and mass spectrometry, to identify new antibiotics produced by this collection of bacteria. Students will develop a broad range of skills in each of these areas and will use these to increase the antimicrobial drug discovery pipeline.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

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