How do neurons maintain their specialised status?
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Department / Centre
- Anatomy and Neuroscience
- Peter MacCallum Cancer Institute
|Dr Louise Chengemail@example.com||Personal web page|
Summary The lab is interested in identifying novel transcription factors that regulate this process, and investigate whether these factors are involved in regeneration.
The bidirectional conversion between differentiated cells and stem cells often underlies carcinogenesis. Mechanisms must be in place to prevent differentiated cells from reverting to multipotent stem cells. We have recently discovered that zinc finger transcription factor Nerfin-1 is required to maintain neurons in a differentiated state (Froldi et al., 2015). In the absence of Nerfin-1, neurons rapidly increase their cellular growth and switch on stem cell markers, then form tumours.
Dr Louise Cheng, Research Project Leader & Head of Laboratory
Dr Patricia Jusuf, School of Biosciences, University of Melbourne
Froldi F, Pachnis P, Szuperák M, Costas O, Fernando T, Gould AP, Cheng LY. Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in the Drosophila CNS. EMBO J, 2019. (Cover Image). PMID: 30804004
Vissers JHA#, Froldi F#, Schroder J, Papenfuss AT, Cheng LY*, Harvey KF* (2018). The Scalloped and Nerfin-1 transcription factors cooperate to maintain neuronal cell fate. Cell Rep. Nov 6;25(6): 1561-1567 (# equal contribution, *Joint senior authors). PMID: 30404010
Froldi F, Szuperak M, Weng CF, Shi W, Pappenfus T, Cheng LY (2015). The transcription factor Nerfin-1 prevents reversion of neurons into neural stem cells. Genes Dev. 29(2):129-143. PMID: 25593306
Cheng LY, Bailey AP, Leevers SJ, Ragan TJ, Driscoll PC, Gould AP (2011). Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. Cell. 146(3):435–447. PMID: 21816278
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PhD students, Masters by Research, Honours students
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Research NodePeter MacCallum Cancer Institute
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