Neuroinflammation and its contribution to an autism-like phenotype

Research Opportunity
PhD students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Prof Peter Clark pcrack@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Juliet Taylor
A/Prof Elisa Hill

Summary The Crack and Taylor group is run by Professor Peter Crack and Dr Juliet Taylor. The Neuropharmacology laboratory looks to understand how fundamental cellular signalling pathways can predispose the brain to exacerbated neurotrauma or neuropathology. In understanding how these pathways contribute to neural dysfunction we may be able to identify novel therapeutics that can be used to combat traumatic brain injury, Alzheimer’s disease and Parkinson’s disease.

Project Details

There is growing evidence in the literature that neuroinflammation plays a role in cognitive function. Microglial activation has been shown to be involved in synapse formation and maintenance. Recent studies have suggested that neuro-inflammation plays a growing role in the pathogenesis of autism spectrum disorder (ASD). Previous work from our laboratory highlights that the type-I interferon (IFN) system is a master regulator of neuroinflammation in both acute and chronic neuropathology. This project will ultilise a well-established genetic mouse model of autism and investigate if there is any attributable effect to type-I IFN signalling in the progression of the autism like phenotype in this mouse.
Skill acquisition: In vivo disease models, histology, immunohistochemistry, morphometry, quantitative PCR, FACS analysis of cell populations, cell and tissue culture, ELISA, molecular biology and western blotting.



Research Opportunities

PhD students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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