Neurodegeneration in the enteric nervous system

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Associate Professor Vicki Lawson vlawson@unimelb.edu.au Personal web page

Summary This project investigates the consequences of the loss of neuronal populations and neuroinflammation in the enteric nervous system from mouse models of neurodegeneration (prion disease, Parkinson’s disease, Amyotrophic lateral sclerosis) and exploring diagnostic paradigms utilising tissues from the gastrointestinal tract.

Project Details

The enteric nervous system controls the function of the gastrointestinal tract and depends on extrinsic innervation arising from the brain and spinal cord, and intrinsic innervation derived from neurons within the neuronal plexus of the gastrointestinal tract. Recent studies suggest that neurons and glial cells of the enteric nervous system are vulnerable to the degeneration that is observed in the neurons and glial cells of the central nervous system (Albanese et al 2008, Lawson et al 2010, Ellet et al 2016). We are interested in parallels in disease (pathology and pathogenesis) observed in the enteric and central nervous system in neurodegeneration, and the potential for neurodegeneration to originate in the enteric nervous system. This project investigates the consequences of the loss of neuronal populations and neuroinflammation in the enteric nervous system from mouse models of neurodegeneration (prion disease, Parkinson’s disease, Amyotrophic lateral sclerosis) and exploring diagnostic pa​radigms utilising tissues from the gastrointestinal tract.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Lawson laboratory: Neurodegenerative disease caused by prions

Research Node

Doherty Institute

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