Neural regulation of anti-cancer immunity

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Associate Professor Scott Mueller smue@unimelb.edu.au (03) 8344 9044 Personal web page
Co-supervisor Email Number Webpage
Dr Sapna Devi sapna.devi@unimelb.edu.au 8344 5715

Summary This project will investigate sympathetic innervation of tumours and how neural signals impact immune responses in the tumour microenvironment, in order to design new therapies to treat cancer.

Project Details

Tissues are innervated by fibres of the sympathetic nervous system (SNS), which release SNS neurotransmitters during stress. SNS neurotransmitters bind to adrenoceptors (ARs) on multiple cell types to induce genomic and functional changes. Studies have shown that immunity is compromised during times of stress raising the possibility that SNS signalling impairs immune cell functions. However, little is known about the mechanisms of SNS neurotransmitter signalling on the cells of the immune system. We have discovered that adrenergic receptor signalling inhibits the migration of immune cells within tissues, and impacts protective immunity against infections and cancer. This project will investigate sympathetic innervation of tumours and how neural signals impact immune responses in the tumour microenvironment, in order to design new therapies to treat cancer.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Mueller laboratory: Visualising the immune system in action

Research Node

Doherty Institute

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