MRGPRX2-mediated drug hypersensitivity drug reactions.
- Research Opportunity
- PhD students, Honours students, Master of Biomedical Science
- Number of Honour Places Available
- 1
- Number of Master Places Available
- 1
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| Dr Graham Mackay | gmackay@unimelb.edu.au | Personal web page |
Summary Our team is focussed largely around the fascinating mast cell and its role in allergic and non-allergic disease. In particular, we want to better understand how these cells are activated, the mediators they release and if we can translate this knowledge to generating new therapeutics.
Project Details
Exciting new work has identified that mast cells have a receptor called MRGPRX2 that can be directly activated by many clinically used drugs including certain antibiotics. This might explain a significant number of drug hypersensitivity reactions. However, it is unclear as to why only some individuals react so adversely to these drugs. In this project you will examine mast cell activation through MRGPRX2 and identify pathways that enhance the activity of this pathway. This information will hopefully be of utility in better understanding, predicting and treating MRGPRX2-mediated drug hypersensitivity.Research Opportunities
PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
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