MRGPRX2-mediated drug hypersensitivity drug reactions.

Research Opportunity
PhD students, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Primary Supervisor Email Number Webpage
Dr Graham Mackay gmackay@unimelb.edu.au Personal web page

Summary Our team is focussed largely around the fascinating mast cell and its role in allergic and non-allergic disease. In particular, we want to better understand how these cells are activated, the mediators they release and if we can translate this knowledge to generating new therapeutics.

Project Details

Exciting new work has identified that mast cells have a receptor called MRGPRX2 that can be directly activated by many clinically used drugs including certain antibiotics. This might explain a significant number of drug hypersensitivity reactions. However, it is unclear as to why only some individuals react so adversely to these drugs. In this project you will examine mast cell activation through MRGPRX2 and identify pathways that enhance the activity of this pathway. This information will hopefully be of utility in better understanding, predicting and treating MRGPRX2-mediated drug hypersensitivity. 



Research Opportunities

PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


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