MR1 – a molecular alarm system for bacterial infection
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Department / Centre
- Microbiology and Immunology
- Doherty Institute
|Dr Hamish McWilliamfirstname.lastname@example.org||(03) 9035 7698||Personal web page|
|Professor Jose Villadangosemail@example.com||(03) 9035 7684||Personal web page|
Summary This project will use a novel MR1-reporter mouse model to discover which cells are armed with MR1 during various disease settings, and CRISPR/Cas9 gene editing to understand how MR1 works in these cells.
MR1 is a molecular alarm to alert the immune system during bacterial infection. It captures metabolite by-products from bacteria and presents them to a highly abundant T cell subset, called mucosal-associated invariant T (MAIT) cells. The MR1-MAIT cell system is a highly conserved piece of the immune repertoire to detect important bacterial pathogens, yet basic aspects are not understood such as which cells express MR1 in vivo. This project will use a novel MR1-reporter mouse model to discover which cells are armed with MR1 during various disease settings, and CRISPR/Cas9 gene editing to understand how MR1 works in these cells.
Faculty Research Themes
School Research Themes
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Department / Centre
Research Group / Unit / Centre
Research NodeDoherty Institute
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