MR1 – a molecular alarm system for bacterial infection

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Hamish McWilliam hamish.mcwilliam@unimelb.edu.au (03) 9035 7698 Personal web page
Co-supervisor Email Number Webpage
Professor Jose Villadangos j.villadangos@unimelb.edu.au (03) 9035 7684 Personal web page

Summary This project will use a novel MR1-reporter mouse model to discover which cells are armed with MR1 during various disease settings, and CRISPR/Cas9 gene editing to understand how MR1 works in these cells.

Project Details

MR1 is a molecular alarm to alert the immune system during bacterial infection. It captures metabolite by-products from bacteria and presents them to a highly abundant T cell subset, called mucosal-associated invariant T (MAIT) cells. The MR1-MAIT cell system is a highly conserved piece of the immune repertoire to detect important bacterial pathogens, yet basic aspects are not understood such as which cells express MR1 in vivo. This project will use a novel MR1-reporter mouse model to discover which cells are armed with MR1 during various disease settings, and CRISPR/Cas9 gene editing to understand how MR1 works in these cells.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

Villadangos laboratory: Antigen presenting cells & molecules that initiate T cell immunity against pathogens and cancer

Research Node

Doherty Institute

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