Molecular basis for growth factor surveillance in plasmacytoid dendritic cells
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Department / Centre
- Microbiology and Immunology
- Doherty Institute
|Dr Alexander David Barrowemail@example.com||(03) 9035 6297||Personal web page|
|Dr Theo Mantamadiotisfirstname.lastname@example.org||Personal web page|
Summary The Barrow group are interested in identifying how the GF and TLR signaling pathways intersect to enhance IFN-I secretion by pDCs to evoke effective anti-viral immunity.
Plasmacytoid dendritic cells (pDCs) are rare cells that secrete large quantities of type-I interferon (IFN-I) in response to viral infections. Some viruses encode growth factors (GFs) to induce proliferative lesions that are required for host infectivity. We have found that some GFs can enhance IFN-I production by pDCs. These results suggest that GFs can synergise with toll-like receptors (TLRs) to enhance IFN-I secretion by pDCs. The Barrow group are interested in identifying how the GF and TLR signalling pathways intersect to enhance IFN-I secretion by pDCs to evoke effective anti-viral immunity.
Faculty Research Themes
School Research Themes
PhD students, Masters by Research, Honours students
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Department / Centre
Research NodeDoherty Institute
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