Molecular basis for growth factor surveillance in plasmacytoid dendritic cells

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Alexander David Barrow alexanderdav@unimelb.edu.au (03) 9035 6297 Personal web page
Co-supervisor Email Number Webpage
Dr Theo Mantamadiotis theom@unimelb.edu.au Personal web page

Summary The Barrow group are interested in identifying how the GF and TLR signaling pathways intersect to enhance IFN-I secretion by pDCs to evoke effective anti-viral immunity.

Project Details

Plasmacytoid dendritic cells (pDCs) are rare cells that secrete large quantities of type-I interferon (IFN-I) in response to viral infections. Some viruses encode growth factors (GFs) to induce proliferative lesions that are required for host infectivity. We have found that some GFs can enhance IFN-I production by pDCs. These results suggest that GFs can synergise with toll-like receptors (TLRs) to enhance IFN-I secretion by pDCs. The Barrow group are interested in identifying how the GF and TLR signalling pathways intersect to enhance IFN-I secretion by pDCs to evoke effective anti-viral immunity.



Faculty Research Themes

Infection and Immunology, Cancer

School Research Themes

Infection & Immunity, Cancer in Biomedicine



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

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