Molecular basis for growth factor surveillance in plasmacytoid dendritic cells
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Department / Centre
- Microbiology and Immunology
- Doherty Institute
|Dr Alexander David Barrowfirstname.lastname@example.org||(03) 9035 6297||Personal web page|
|Dr Theo Mantamadiotisemail@example.com||Personal web page|
Summary The Barrow group are interested in identifying how the GF and TLR signaling pathways intersect to enhance IFN-I secretion by pDCs to evoke effective anti-viral immunity.
Plasmacytoid dendritic cells (pDCs) are rare cells that secrete large quantities of type-I interferon (IFN-I) in response to viral infections. Some viruses encode growth factors (GFs) to induce proliferative lesions that are required for host infectivity. We have found that some GFs can enhance IFN-I production by pDCs. These results suggest that GFs can synergise with toll-like receptors (TLRs) to enhance IFN-I secretion by pDCs. The Barrow group are interested in identifying how the GF and TLR signalling pathways intersect to enhance IFN-I secretion by pDCs to evoke effective anti-viral immunity.
Faculty Research Themes
School Research Themes
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
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Department / Centre
Research NodeDoherty Institute
MDHS Research library
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