Molecular basis for growth factor surveillance in natural killer cells

Research Opportunity
PhD, Masters by Research, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Dr Alexander David Barrow alexanderdav@unimelb.edu.au

Summary The Barrow group are determining the functions of the different NKp44 isoforms and how they impact NK cell surveillance of cancers expressing PDGF-D.

Project Details

Many tumours secrete Platelet-derived growth factor (PDGF)-D to promote tumour growth. NK cells have evolved the activating ITAM receptor NKp44 to sense the expression of PDGF-D and trigger the secretion of cytokines that halt tumour growth. An alternatively spliced NKp44 isoform encodes an ‘ITIM’ that is predicted to be inhibitory and is associated with poor survival in cancer. Tumours may induce this inhibitory NKp44 form to dampen NK cell function as a form of immune evasion. The Barrow group are determining the functions of the different NKp44 isoforms and how they impact NK cell surveillance of cancers expressing PDGF-D.



Faculty Research Themes

Cancer, Infection and Immunology



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Node

Doherty Institute

MDHS Research library
Explore by researcher, school, project or topic.