Molecular basis for growth factor surveillance in natural killer cells
- Research Opportunity
- PhD, Masters by Research, Honours
- Microbiology and Immunology
- Doherty Institute
|Dr Alexander David Barrowemail@example.com|
Summary The Barrow group are determining the functions of the different NKp44 isoforms and how they impact NK cell surveillance of cancers expressing PDGF-D.
Many tumours secrete Platelet-derived growth factor (PDGF)-D to promote tumour growth. NK cells have evolved the activating ITAM receptor NKp44 to sense the expression of PDGF-D and trigger the secretion of cytokines that halt tumour growth. An alternatively spliced NKp44 isoform encodes an ‘ITIM’ that is predicted to be inhibitory and is associated with poor survival in cancer. Tumours may induce this inhibitory NKp44 form to dampen NK cell function as a form of immune evasion. The Barrow group are determining the functions of the different NKp44 isoforms and how they impact NK cell surveillance of cancers expressing PDGF-D.
Faculty Research Themes
PhD, Masters by Research, Honours
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Research NodeDoherty Institute
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