Metal ion homeostasis in Klebsiella pneumoniae

Research Opportunity
PhD, Honours
Department
Microbiology and Immunology
Location
Doherty Institute
Primary Supervisor Email Number Webpage
Associate Professor Christopher McDevitt christopher.mcdevitt@unimelb.edu.au (03) 8344 7200 Personal web page
Co-supervisor Email Number Webpage
Dr Aimee Tan aitan@unimelb.edu.au (03) 9035 4473 Personal web page

Summary Our recent studies investigating the chemical biology of this bacterium have identified numerous uncharacterised pathways involved in the acquisition of essential metal ion nutrients, such as zinc and molybdenum, from the host. This project will provide the first descriptions of these pathways and how they contribute to the growth, virulence and antibiotic resistance of Klebsiella pneumoniae.

Project Details

Klebsiella pneumoniae is a globally significant multi-drug resistant pathogen. Our recent studies investigating the chemical biology of this bacterium have identified numerous uncharacterised pathways involved in the acquisition of essential metal ion nutrients, such as zinc and molybdenum, from the host. This project will provide the first descriptions of these pathways and how they contribute to the growth, virulence and antibiotic resistance of Klebsiella pneumoniae. The outcomes of this study will provide information essential to exploiting nutrient dependency in breaking multi-drug resistance in Klebsiella pneumoniae and other Gram-negative bacteria.



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity



Research Opportunities

PhD, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Microbiology and Immunology

Research Group / Unit / Centre

McDevitt laboratory

Research Node

Doherty Institute

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