Manipulating immunity to fight infection and tumours
- Research Opportunity
- PhD students, Honours students, Master of Biomedical Science
- Department / Centre
- Biochemistry and Pharmacology
- Location
- Bio21 Molecular Science and Biotechnology Institute
| Primary Supervisor | Number | Webpage | |
|---|---|---|---|
| A/Prof Justine Mintern | jmintern@unimelb.edu.au | 83442976 | Personal web page |
| Co-supervisor | Number | Webpage | |
|---|---|---|---|
| Professor Jose Villadangos | j.villadangos@unimelb.edu.au | Personal web page |
Summary Vaccination currently represents the most effective strategy for eliminating infectious disease.
Project Details
While many vaccines are in use worldwide, for several pathogens our current vaccines fail with ensuing uncontrolled disease. This is the case for HIV, malaria and tuberculosis resulting in disease and devastation worldwide. Vaccines also have the potential to prevent and/or treat cancer, however this is currently not a clinical reality. Therefore, vaccine design must be advanced, and to do so, we require a more comprehensive understanding of the cell biology involved. A key question in vaccine biology is how are the proteins involved in this response trafficked to and from specialised immune cell compartments. This project will use CRISPR/Cas9 methodology, together with new mouse models of disease, to investigate the consequence of targeting specific components of the molecular machinery that participate in immune cell protein trafficking.
Faculty Research Themes
Cancer, Infection and Immunology
School Research Themes
Cancer in Biomedicine, Molecular Mechanisms of Disease
Research Opportunities
PhD students, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
Key Contact
For further information about this research, please contact a supervisor.
Department / Centre
Research Group / Unit / Centre
Research Node
Bio21 Molecular Science and Biotechnology InstituteMDHS Research library
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